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Technical Specialist, Metabolite Identification





Posted: 23/06/2022

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We offer:

-Vibrant and dynamic employment – we are a highly specialised, growth company operating in a critical sector of the economy – our future is strong and exciting

-Opportunities to develop your skills and yourself – our rapid growth brings greater opportunities for you to learn and grow faster!

-A great team where we all support each other – enjoy your work – after all you spend about a third of your time here!

Our Company: “We are a dynamic, fast-growing company, with an enviable reputation for leading edge science, offering contract research services to some of the world’s leading pharmaceutical companies, solving what were believed to be unsolvable scientific challenges”.

We believe in our ability to relentlessly push forward the boundaries of scientific excellence, delivering solutions for our clients, always operating ethically and with integrity. We take pride in our professionalism and commitment to always deliver our very best work.

The role is based in Northamptonshire, in the town of Rushden. The Rushden site is a centre of excellence for Radiolabelled Sciences incorporating both Metabolism (which includes Clinical Metabolism, Pre-clinical ADME, In vitro and DDI services, Large Molecule Metabolism, Environmental Fate, Plant Metabolism and Metabolite Identification) in addition to Chemistry (which includes API and IMP manufacture). We offer our employees a supportive teamwork environment, enabling them to develop and liberate their true potential.

The position we are seeking to fill is for a Technical Specialist, Metabolite Identification to bring their expertise in High Resolution Mass Spectrometry to identify metabolites generated in studies for new product development based on global regulatory requirements.

* We offer state of the art equipment and facilities at our Rushden site

* We offer a competitive salary and a progressive and comprehensive suite of employee benefits


-PhD, MSc or BSc (Hons) in Chemistry, Biochemistry or related subject

-Experience in metabolite identification in a CRO or Pharmaceutical/Agrochemical company.

-Experience in chromatographic method development

-Experience of working in a GLP facility

-Proficient in use of High Resolution Mass Spectrometers e.g. Waters Vion, Thermo QExactive

-Proficient in use of relevant software e.g. Xcalibur, Waters UNIFY, Compound Discoverer

-Knowledge of metabolism/metabolic reactions

-LC-MS/MS data interpretation skills

-Coaching & Mentoring

-Project Management

-Scientific data interpretation, reporting and presentation skills

-Effective written and verbal communication skills, including the ability to effectively present scientific findings to colleagues and clients

-Good knowledge of Microsoft Office software


The successful candidate will have responsibilities for:

-Bringing expertise in structure elucidation.

-Conducting analytical and metabolite identification work for both regulatory and non‑regulatory In Vitro, In Vivo, Clinical, Large Molecule (Biological) and Environmental-Fate studies to successfully fulfil all the requirements of a study to the timelines stated in the Study Plan/Analytical Work Plan, under direction of the Study Director or Analytical Project Manager.

-Being responsible for the development of LC‑MS/MS chromatographic methods within the group and to act as an expert consultant on the development of chromatographic methods within the wider Metabolism Department.

-Developing training materials and delivering training in area of specialism.

-Leading process improvement/new service development projects in their specialist area.

-Holding equipment/software/ lab space responsibilities on behalf of their team.

-Increasing profile of the department externally by publishing papers/posters and participation in expert groups.

-Working with Study Director on client communication, contributing scientifically to client discussions, as appropriate.

-Interpreting the relevant data and prepare accurate scientific study updates and contribute to reports.

-Addressing findings appropriate to area arising from QA audits and process inspections.

-Maintaining and writing SOPs, as required.

Why Should You Apply?

-This is an opportunity for you as a Technical expert in High Resolution Mass Spectrometry to demonstrate your ability to make a real impact in a highly scientific and regulated environment

-To be part of a team who support each other and put excellence at the heart of all that we do

Pharmaron is a premier R&D service company supporting the life sciences industry. Founded in 2003, Pharmaron has invested in its people and facilities having established diverse drug R&D service capabilities, ranging from synthetic, medicinal and analytical chemistry, biology, DMPK, pharmacology, drug safety assessment, radiochemistry and isotopically labelled metabolism, chemical & pharmaceutical development to clinical development. With operations in China, US and UK staffed by over 12,000 employees, Pharmaron has an excellent track record in the delivery of R&D solutions to its partners in North America, Europe, Japan and China

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